Wednesday, March 28, 2012

Study finds circle hooks lower catch rate for offshore anglers

Study finds circle hooks lower catch rate for offshore anglers [ Back to EurekAlert! ] Public release date: 28-Mar-2012
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Contact: Matt Shipman
matt_shipman@ncsu.edu
919-515-6386
North Carolina State University

Anglers are required to use circle hooks in some fishing tournaments because they are less likely to cause lethal injuries in billfish, such as marlin. However, research from North Carolina State University shows that broadening circle hook requirements could adversely impact charter and recreational fishing, since they make it more difficult to catch non-billfish.

"We wanted to know whether circle hooks are effective as conventional J hooks when angling for non-billfish such as yellowfin tuna in North Carolina waters," says Paul Rudershausen, a research assistant in NC State's biology department and lead author of a paper describing the research. The NC State team worked with charter boat captains and mates who were experienced with use of circle hooks to look at the efficacy of circle hooks versus J hooks when trolling offshore with rod and reel. The findings are relevant for similar fishing efforts in other waters where these same species occur.

A "circle hook" is defined as a circular hook in which the point of the hook is perpendicular to and aligned with the shank of the hook. This differs from a J hook, which is shaped like the letter J.

Studies have found that circle hooks are less likely to mortally wound billfish during recreational or charter fishing. As a result, the National Marine Fisheries Service instituted regulations requiring anglers in Atlantic billfish tournaments to use circle hooks when using natural baits. J hooks are still permitted if an angler is using purely artificial bait.

Anglers and fishing industry observers have speculated about the possibility that circle hook regulations may be expanded to fishing outside of billfish tournaments even when anglers are not fishing for billfish to protect billfish species that may be caught inadvertently.

This speculation led NC State researchers to determine whether circle hooks would be as effective as J hooks when fishing for non-billfish species. The answer is no.

The researchers looked at the relative effectiveness of circle and J hooks for three popular sporting fish: dolphinfish (often called mahi mahi in the Pacific), yellowfin tuna and wahoo. "Circle hooks were roughly 60 to 70 percent as effective at catching these three species as J hooks," Rudershausen says.

The researchers found that the fish would still strike at the bait, but that the hook was significantly less likely to set in the mouth of the fish. However, when the hook did set, anglers were just as likely to be able to get the fish to the boat.

"The charter ocean fishing industry is economically significant in North Carolina," Rudershausen says, "receiving approximately $65 million in for-hire fees in 2009. The concern is that circle hooks would drive down catch rates which could result in fewer clientele for North Carolina's offshore charter fishing industry."

The researchers hope to work with economists to better capture the potential economic impact of any expansion of circle hook regulations.

###

The paper, "A comparison between circle hook and J hook performance in the troll fisheries off North Carolina," was co-authored by Dr. Jeffrey Buckel, associate professor of biology at NC State; Greg Bolton, laboratory research specialist in NC State's Department of Food, Bioprocessing & Nutrition Sciences, Tyler Averett, a former technician at NC State; Randy Gregory of the North Carolina Division of Marine Fisheries; and Paul Conn of the National Marine Fisheries Service. The paper is available online from Fishery Bulletin. The cooperating charter boat captains were Dale Britt on the F/V Sensation and Pete Zook on the F/V Energizer. The research was supported by North Carolina's Fishery Resource Grant program which is administered by NC Sea Grant.



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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Study finds circle hooks lower catch rate for offshore anglers [ Back to EurekAlert! ] Public release date: 28-Mar-2012
[ | E-mail | Share Share ]

Contact: Matt Shipman
matt_shipman@ncsu.edu
919-515-6386
North Carolina State University

Anglers are required to use circle hooks in some fishing tournaments because they are less likely to cause lethal injuries in billfish, such as marlin. However, research from North Carolina State University shows that broadening circle hook requirements could adversely impact charter and recreational fishing, since they make it more difficult to catch non-billfish.

"We wanted to know whether circle hooks are effective as conventional J hooks when angling for non-billfish such as yellowfin tuna in North Carolina waters," says Paul Rudershausen, a research assistant in NC State's biology department and lead author of a paper describing the research. The NC State team worked with charter boat captains and mates who were experienced with use of circle hooks to look at the efficacy of circle hooks versus J hooks when trolling offshore with rod and reel. The findings are relevant for similar fishing efforts in other waters where these same species occur.

A "circle hook" is defined as a circular hook in which the point of the hook is perpendicular to and aligned with the shank of the hook. This differs from a J hook, which is shaped like the letter J.

Studies have found that circle hooks are less likely to mortally wound billfish during recreational or charter fishing. As a result, the National Marine Fisheries Service instituted regulations requiring anglers in Atlantic billfish tournaments to use circle hooks when using natural baits. J hooks are still permitted if an angler is using purely artificial bait.

Anglers and fishing industry observers have speculated about the possibility that circle hook regulations may be expanded to fishing outside of billfish tournaments even when anglers are not fishing for billfish to protect billfish species that may be caught inadvertently.

This speculation led NC State researchers to determine whether circle hooks would be as effective as J hooks when fishing for non-billfish species. The answer is no.

The researchers looked at the relative effectiveness of circle and J hooks for three popular sporting fish: dolphinfish (often called mahi mahi in the Pacific), yellowfin tuna and wahoo. "Circle hooks were roughly 60 to 70 percent as effective at catching these three species as J hooks," Rudershausen says.

The researchers found that the fish would still strike at the bait, but that the hook was significantly less likely to set in the mouth of the fish. However, when the hook did set, anglers were just as likely to be able to get the fish to the boat.

"The charter ocean fishing industry is economically significant in North Carolina," Rudershausen says, "receiving approximately $65 million in for-hire fees in 2009. The concern is that circle hooks would drive down catch rates which could result in fewer clientele for North Carolina's offshore charter fishing industry."

The researchers hope to work with economists to better capture the potential economic impact of any expansion of circle hook regulations.

###

The paper, "A comparison between circle hook and J hook performance in the troll fisheries off North Carolina," was co-authored by Dr. Jeffrey Buckel, associate professor of biology at NC State; Greg Bolton, laboratory research specialist in NC State's Department of Food, Bioprocessing & Nutrition Sciences, Tyler Averett, a former technician at NC State; Randy Gregory of the North Carolina Division of Marine Fisheries; and Paul Conn of the National Marine Fisheries Service. The paper is available online from Fishery Bulletin. The cooperating charter boat captains were Dale Britt on the F/V Sensation and Pete Zook on the F/V Energizer. The research was supported by North Carolina's Fishery Resource Grant program which is administered by NC Sea Grant.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-03/ncsu-sfc032812.php

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Source: http://blog.ultimatemarketingstrategies.net/self-improvement-programs-that-work-self-help

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Sunday, March 25, 2012

'Hunger Games' debut is 3rd best opening ever

By Pamela McClintock, The Hollywood Reporter

Lionsgate

Jennifer Lawrence stars as "Katniss Everdeen" in "The Hunger Games."

Making history, Lionsgate's "The Hunger Games" opened to an astounding $155 million at the domestic box office, the third-best debut of all time and the best for any film opening outside of summer.

"Hunger Games" -- the big-screen adaptation of?Suzanne Collins' best-selling young-adult novel starring Jennifer Lawrence, Josh Hutcherson and Liam Hemsworth -- also reeled in the biggest opening for a nonsequel.

"It was the perfect storm. Having the first film in a franchise to be so gigantic is amaing. We had a great book, and a great director in Gary Ross," said Lionsgate president of marketing Tim Palen, whose team is credited with a savvy campaign.

Domestic box office revenues were up a whopping 78 percent from a year ago, thanks to the might of "Hunger Games," which changes the fortunes of Lionsgate and gives the studio an instant tentople franchise. Lionsgate will make three more films by splitting the final book in Collins' trilogy into two movies.

Exclusive THR photos: Behind the scenes of THR's 'Hunger Games' cover shoot

Overseas, "Hunger Games" turned in a more muted performance for a solid bow of $59.3 million from 67 markets. The foreign tally, which came in ahead of the international debut of the first "Twilight" film, puts "Hunger Games' "?worldwide opening at $214.3 million.

"Hunger Games" is projected to place No. 1 in virtually every foreign market, but did best in English-speaking territories, and particularly Australia, where it debuted to $6.7 million. "Hunger Games" turned in $7.5 million in the U.K., despite unseasonably warm weather, which often keeps consumers outside.

In North America, the tentpole came in not far behind the $158.4 million earned by "The Dark Knight" in its July 2008 debut. "Harry Potter and the Deathly Hallows Part 2" holds the record for best debut with $169.2 million in summer 2011.

Among the past films that "Hunger Games" surpassed in its opening weekend were "Spider-Man 3" ($151.1 million in 2007), "The Twilight Saga: New Moon" ($142.8 million in 2009) and "The Twilight Saga: Breaking Dawn Part 1" ($138.1 million last year).

"Hunger Games" drew an A CinemaScore overall on Friday night, with those under the age of 25 giving it a glowing A+ and those over 25 an A-. Tweens and teens turned out in force for the film, with 39 percent of the audience younger than 18, according to CinemaScore exit polling.

THR photos: 'Hunger Games' mall tour

Part of the movie's strength is that it is appealing to males as well as females, unlike the femme-heavy "Twilight" franchise, another blockbuster film property based on a young-adult book series. Males made up 39 percent of "Hunger Games' "?Friday night audience.

"The numbers just kept growing and growing. And based on the trajectory of the weekend, we are going to have an unbelievable hold. We are going to play and play," Lionsgate executive vice president of distribution David Spitz said. "I think that when we initially looked at this property, we thought we were going to have "Twilight" numbers in terms of females, but we didn't."

"Hunger Games" also played like a family film, evidenced by its strong Friday to Saturday hold. The film fell a narrow 25 percent, while the "Twilight" and "Harry Potter" films fall anywhere from 44 percent to 60 percent.

According to CinemaScore, 49 percent of those showing up to see "Hunger Games" were under the age of 25; Lionsgate's exit polling showed that 44 percent were under the age of 25.

"Hunger Games" played in a total of 4,137 theaters at the domestic box office, including 268 IMAX theaters, which turned in a hefty $10.6 milion for a per screen average of $40,000, a record for a 2D nonsequel.

THR photos: 10 pre-'Hunger Games' top international film franchises

Elsewhere at the domestic box office, Sony and MGM's Jonah Hill-Channing Tatum comedy "21 Jump Street" stayed strong its opening weekend despite "Hunger Games." The R-rated pic fell 41 percent to $21.3 million, putting its domestic cume at a handy $71.1 million.

Universal and Illumination's "Dr. Seuss' The Lorax" came in No. 3 after "Hunger Games" and "21 Jump Street," grossing $13.1 million in its fourth weekend for an enviable domestic gross of $177.3 million.

Related content:

Source: http://entertainment.msnbc.msn.com/_news/2012/03/25/10855086-hunger-games-earns-155-million-for-third-best-opening-of-all-time

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Methods to Build up Muscle tissue Easily And Obtain Your Perfect ...

The journey to body-building is definitely a prolonged and complex one, but fortunately a handful of ways have been found with the growing knowledge of sports physiology. These strategies will let you create muscle tissue at a substantially quicker pace than usual. The 1st method is that an individual do not have to exercise each muscle group for a long time on a daily basis. In the old fashioned method of muscle development, there would be no tactic to build muscles rapidly. You hit the health and fitness center for two to four hours on daily basis and exercised all your body on daily basis. That has since evolved nowadays.

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Serious weightlifters paid attention and began to train better, looking for tips on how to build muscles speedily. These people still devote extensive amounts of time in the gym, but the difference is it had become approximately 50% of the amount of time they would once devote. Why are they these guys in the position to achieve this? Physical exercises and programs were assessed to get the best procedure to gaining muscles faster, as well as bigger.

Experts found that it would be fundamental to recuperate muscular tissues after they have been toiled strenuously, or else they get fatigued and cannot develop any further.

In the world today, muscle builders are advised to work each group of muscles to extensive weariness only one day a week. Without a doubt, they get some exercise while you focus on different muscles, but that is inevitable. It is only on their ?focus day? that they?re exhausted. Using this methodology fast tracks your muscular growth and gets your entire body robust on the whole. Visit more information on biceps workout here?

There?s no need to deal with constant all-round muscle swelling every day of the week given that muscles able to rest and repair on their own.

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If you are a beginner muscle builder, you will have to seek the strategies of the coach for the easiest way for you to shed weight and build muscle tissue. The fitness instructor at your nearby fitness gym would be the sensible individual to visit. They will certainly establish a program suitable for you which exercises each individual muscle to downright exhaustion one or more times in a week. Find out about great tips on six pack abs here?

To sum up, the route to easy muscle growth depends upon exercising each muscle smarter, not harder. Rest is undoubtedly as important as weight training, and choosing a cautious diet program is certainly the most fundamental of all.

Related posts:

  1. Build Big Muscle By Losing Fat Nowadays, the measure of being sexy is by the number...
  2. 5 Top Tips To Build Muscle Mass Fast If you?re looking for strategies to build muscle mass fast,...
  3. muscle building & fat reduction More and more individuals are focusing on their personal existence...
  4. How to Increase Muscle Size If you?ve been lifting weights for more than a few...
  5. Beginner Workout for More Muscle Mass Piecing together a starter exercise session is often complicated as...

Source: http://www.goodgoing24.com/methods-to-build-up-muscle-tissue-easily-and-obtain-your-perfect-figure/

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Saturday, March 24, 2012

Engadget Podcast 286 - 03.23.2012

We'd normally use this space to give you a little insight into what might happen on this week's edition of the Engadget Podcast but if you're reading this, you probably already know, and Tim's not around this week to tell us how to run things, so we'll just go ahead and do the practical thing here and try to attract a couple new demographics by telling you that this episode of the Engadget Podcast is the perfect companion to waiting in line for The Hunger Games alone after school at the mall for an hour and change.

Host: Brian Heater
Guests: Terrence O'Brien, Billy Steele
Producer: Trent Wolbe
Music: Orbital - Never

00:06:15 - iPad review (2012)
00:15:50 - Apple touts three million new iPads sold since launch
00:22:00 - Apple: don't worry about hot iPad reports, it's cool
00:28:00 - Apple announces dividend and share repurchase program for 2012, expects to spend $45 billion over three years
00:32:44 - Samsung Galaxy Note 10.1 preview (video)
00:40:25 - Samsung Galaxy Tab 7.7 review (Verizon Wireless LTE)
00:48:21 - Wacom Intuos5 touch review
00:53:45 - Samsung Rugby Smart review
00:59:30 - Angry Birds Space now available for download, pigs will fly
01:03:50 - Listener questions

Hear the podcast

Subscribe to the podcast

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[Zune] Subscribe to the Podcast directly in the Zune Marketplace.


Download the podcast

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Contact the podcast


Send your questions to @tim_stevens.
Leave us a voicemail: (423) 438-3005 (GADGET-3005)
E-mail us: podcast at engadget dot com
Twitter: @bheater, @terrenceobrien, @wmsteele

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Engadget Podcast 286 - 03.23.2012 originally appeared on Engadget on Fri, 23 Mar 2012 15:08:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/03/23/engadget-podcast-286-03-23-2012/

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gstar jeans Finance Philanthropy Charitable Giving - Matthewclar6's ...

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Source: http://matthewclark1.typepad.com/blog/2012/03/gstar-jeans-finance-philanthropy-charitable-giving.html

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Friday, March 23, 2012

Effective Search Engine Optimization Can Help You Develop A ...

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Source: http://homegrownwebmarketing.com/effective-search-engine-optimization-can-help-you-develop-a-successful-company

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Thursday, March 22, 2012

A DIY guide to improving your brain

Samantha Murphy, contributor

9781444708806.jpgIT IS often said that psychology is both an art and a science. While the cognitive and behavioural practices have made great strides toward a more empirical approach to understanding the human mind, a gap remains. Sexy neuroscience studies with colourful pictures of activated brain regions have seduced psychologists and the public alike, but without a handy MRI scanner to become familiar with your own circuitry, they are not that useful for most of us.

The Emotional Life of Your Brain by pioneer neuroscientist and psychiatrist Richard J. Davidson and science writer Sharon Begley closes that gap. The authors take us on an investigative neuroscience adventure that ultimately leads to the creation of a new model for understanding emotions.

To find one's "Emotional Style", Davidson refers to six dimensions of emotion he identified in his 30 years of brain research: attention, resilience, outlook, self-awareness, social intuition and sensitivity to context. These reflect the way our brains process information.

Useful enough, but perhaps the most stimulating element of this book is the set of simple 10-question surveys he includes. These correspond with volumes of neuroscience studies that measure patterns of activation in brain regions associated with the different emotional dimensions.

The ultimate goal of finding these patterns in brain activity, says Davidson, is what he refers to as "neurally inspired behaviour therapy". With the discovery of neuroplasticity, Davidson illustrates how "the mind can change the brain" through the use of cognitive-behavioural interventions. He even goes on to suggest some exercises.

For example, if you scored as "unfocused" on the attention scale and you would like to be more attentive, he suggests spending 10 minutes a day focusing on one inanimate object, increasing this by 10 minutes each month until you reach an hour. This practice, he says, will change your brain until deeper attention becomes natural.

With a message of hope and empowerment and a surprising degree of clarity for one of humanity's most complex topics, this book may finally be the world's first introduction to the extremely scientific future of psychology.

Book Information
The Emotional Life of Your Brain
by Richard J. Davidson and Sharon Begley
Published by: Hudson Street Press
$25.95

Source: http://feeds.newscientist.com/c/749/f/10897/s/1daf6812/l/0L0Snewscientist0N0Cblogs0Cculturelab0C20A120C0A30Ca0Ediy0Eguide0Eto0Eimproving0Eyour0Ebrain0Bhtml0DDCMP0FOTC0Erss0Gnsref0Fonline0Enews/story01.htm

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Researchers solve Darwin's puzzle

It is a clever trick if you can pull it off - mimic another, more dangerous animal and so avoid being eaten.

Many insects try it, but it has been a long standing puzzle why some of the worst mimics in Nature can still seem to escape becoming a meal.

Now, Canadian scientists tell Nature journal they can answer that one.

Larger animals, they say, make for more substantial meals, and so their mimicry needs to be spot on. For small prey, a great performance is not so essential.

"Mimicry of harmless species pretending to be dangerous ones in order to avoid being eaten is one of the best celebrated examples of the outcome of evolution by natural selection," says Professor Tom Sherratt, of Carleton University in Ottawa, who led the research.

"Good examples of mimicry are highlighted in biology text books, but many mimics are poor and their emergence remains something of a puzzle."

Mimicry is common among plants and animals.

Species of snakes, spiders and butterflies have all evolved to look like other species to ward off predators. But one of the great mysteries in biology is that most of this copy-cat behaviour is not very good, and bad impersonators seem just as abundant as the good ones.

A simplistic interpretation of Darwin's theory of natural selection would suggest that it would be better for all mimics to closely resemble the species they are trying to impersonate.

One explanation for why some might not achieve this is the eye of the beholder theory.

Continue reading the main story

Darwinian discord

Listen to the sound of a wasp followed by a hoverfly trying to sound like a wasp.

Darwinian selection would suggest that over time the hoverflies that sounded most like wasps would be preferentially selected until a species emerged that sounded very nearly, if not exactly, like the creature it was trying to impersonate.

In contrast, the species that were poor mimics would all be eaten and die out.

The new Canadian research suggests why this hasn't happened?

This states that although the mimicking species aren't convincing to humans, they do fool their predators whose senses are quite different to ours. Listen to the sound of a wasp followed by a hoverfly trying to sound like a wasp.

Darwinian selection would suggest that over time the hoverflies that sounded most like wasps would be preferentially selected until a species emerged that sounded very nearly, if not exactly, like the creature it was trying to impersonate.

In contrast, the species that were poor mimics would all be eaten and die out.

The new Canadian research suggests why this hasn't happened?

Another theory is that poor mimics are an amalgamation of unappetising species and so, although they don't resemble any one of them to a predator, they do represent the worst possible combination.

To probe the conundrum further, researchers at Carlton University studied 81 different species of hoverfly, which to varying degrees mimic bees and wasps.

Hoverflies are harmless flies and yet many have evolved a resemblance to wasps and bees to avoid being eaten by birds.

Some species of hoverfly look very close to the bees and wasps they are supposed to resemble, and other species only bear a passing resemblance.

The team began by first quantifying how close each species was to the bee or wasp it was trying to impersonate.

They did this by showing photographs to people and asking them to give each species a score out of 10.

The team then combined these results with an objective score obtained by comparing measurements of the body parts of each species and their bee or wasp counterpart to obtain an overall score for similarity.

The scientists found that the larger the hoverfly species, the closer it resembled the emulated wasp or bee. They also found that the smaller species were not very good mimics at all.

"If you are a small hoverfly then birds are not going to be very interested in you," Prof Sherratt explained.

"You are a relatively unprofitable meal and so the selection on mimicry is relatively weak.

"All you need to do is vaguely look like a wasp, and a bird will be sufficiently deterred to leave you alone because it's just not worth taking the risk if it turned you were a wasp because the benefit is that much smaller.

"But if you are a nice fat juicy hoverfly, you are a substantial meal to a bird, and in those cases you might experience even stronger selection to resemble something like a wasp or bee and therefore gain protection from predators."

Follow Pallab on Twitter

Source: http://www.bbc.co.uk/go/rss/int/news/-/news/science-environment-17446349

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Wednesday, March 21, 2012

Home Remodeling Tips | Home Improvement Ideas

Remodeling your home could be a good way to enhance the worth of one?s home and can also give it an up to date appear. Numerous occasions home remodeling is completed from necessity along with other occasions it?s carried out from want. In both case, by subsequent a couple of easy tips you are able to conserve your self a while and a few cash whenever you visit transform your home.

Prior to you start to rework your home think about these tips:

- Transform exactly where the water is: This really is one from the timeless traditional tips with regards to remodeling your home. This implies to begin inside your bathrooms as well as your kitchen area. This may deliver you the best worth for the home and also the greatest way for you personally to invest your remodeling cash.

- Crown time: An additional fantastic searching remodeling undertaking that will be carried out indoors is possessing a builder set up crown molding all through your home or get it done your self in the event you understand how. This may appear fantastic and make the rooms seem to become bigger than they really are.

- Think about a face raise: An additional method to deliver about an immediate enhancement for your home is by painting the outdoors of it. Occasionally a brand new colour for your outdoors of one?s home can imply all of the distinction within the globe. In the event you do determine to repaint the home just ensure that you employ high quality paint. You are able to conserve some cash by heading with inexpensive paint but this may have you ever both repainting the home in only a few many years or possess a boring searching g home as soon as once more. In the event you use high quality paint, the home will remain searching much better lengthier. Remember to save lots of a little quantity of paint just in case you at any time discover your self using the job of getting to complete a contact up.

- Think about curb appeal: Curb appeal is how your home appears in the road or essentially what others see when passing by. Think about revamping your landscaping by making certain that each one of one?s bushes are reduce back again and all of your trees are trimmed around feasible. You might even wish to consider your remodeling chance to include some new vegetation or trees into your landscaping combine. An additional simple method to improve curb appeal is by renting a stress washer and utilizing it to wash the generate way, below the soffit of one?s home as well as the roof if you?re not scared of heights. Absolutely nothing provides much more curb appeal than a thoroughly clean searching lawn and driveway.

- Know your codes: In the event you strategy on performing lots of the remodeling your self, ensure that you realize what the nearby codes are. This really is effortlessly achieved by going to your nearby code enforcement workplace and asking them if you will find any permits that have to be obtained prior to you begin your function. This could conserve you a instead significant charge if you?re caught remodeling with no allow you had been intended to possess.

In the event you strategy on promoting your home you then obviously wish to go along with the cheaper sprucing up from the home. But when you?re going to remain to get a whilst, you then might want to invest the cash to obtain a little much more as much as date. Both way, remodeling your home is a superb method to include some additional equity to it, even when it does arrive within the type of sweat equity.

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  2. Home Remodeling Tips You should think about
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  4. Home Remodeling Tips Preparing Your Remodeling Undertaking For Worth, Convenience
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Source: http://www.usuae123.com/202/home-remodeling-tips.html

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Payday loan: A Complete overview ? Simple Business Solutions

Payday loans are a short-term hard cash advance, when it is essential the most?usually amongst paydays! Payday loans are a wonderful way to get some hard cash to tide you above to your up coming paycheck. The target of payday loans is to assist you with finances to meet that unforseen requirement. The funds is provided as a cash advance and is right deposited into your personalized checking account, right after which the cash advance funds, in addition a fee, are taken out of your account at the finish of the loan which normally is your following payday.

However, a payday loan is no substitute for long-term fiscal planning. This hard cash advance should only be taken to meet urgent financial desires right up until your following payday. It is only in emergencies that payday loans arrive in handy. Payday loans also bail you out of situations of bounced checks and late payment penalties by generating the proper cash advance available.

Forewarned is forearmed! So it is with payday loans. If you know what this sort of cash advance will expense you, you will be in a greater position to weigh the professionals and cons of opting for it. This way you will also know just what sum you need to pay back again to the payday loan companies.

Your initial stage ought to be to locate out the ideal fee of payday mortgage on offer. Whichever payday mortgage organization you may pick you should know what will be the fastened amount that you will owe upon finishing your payday loan.

Usually most payday financial loan organizations charge around $20 to $30 per $100 of cash advance. To ensure that there are no ambiguities, insist that your closing payday financial loan sum is spelled out in bucks and cents. This will help you know what you need to have to pay, when your payday loan is due.

To judge the best deal, go for the payday loans company that is supplying a lower APR. Usually, most payday financial loan businesses offer a cost-breakdown per 100-dollar increments that coincide with the rate.

Furthermore, most payday mortgage charges are based on the length of the income advance. The standard APR for most companies falls into the 400 % range. As an example, suppose you have been to borrow $100 at a fee of $20 for a 2 week time period and if you did not shell out if for a year, your service cost would be $520 for a 520% APR. To which you need to don?t forget to include the authentic $100 that you borrowed.

There may be a situation where you are unable to repay the complete sum of the cash advance to the payday loans company. In this sort of a situation, the payday loans firm typically fees the cash loans finance payment and defers the principal payment above an extended period of time, usually yet another 14 days.

Related posts:

  1. Legitimate Reasons to Get a Payday Loan
  2. My brother likes Payday loan online or Payday cash advance
  3. BENEFITS OF PAYDAY LOAN
  4. Manage Your Financial With Payday Loan Online
  5. KNOW ABOUT PAYDAY LOAN LAWS

Source: http://www.wkccradio.com/business-finance/payday-loan-a-complete-overview

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Tuesday, March 20, 2012

Sneak Peak of the 2013 Santa Fe | Heller Hyundai's Blog

Hyundai Motor Co., one of the world?s largest and fastest-growing automakers, today unveiled exterior teaser images of the all-new Santa Fe, which had been known by its code name DM in Korea. The all-new Santa Fe will have its world premiere at the New York International Auto Show in early April.

Hyundai will keep the name ?Santa Fe? for the new vehicle, continuing the solid brand heritage of the automaker?s most representative SUV model. The all-new Santa Fe, which is entering its third generation, has reached worldwide cumulative sales of about 2.56 million units (Korea: 680,000 / overseas: 1.95 million) since its 2000 debut.

Based on Hyundai?s design philosophy, Fluidic Sculpture, the new Santa Fe adopts its own design concept called ?Storm Edge,? which captures the strong and dynamic images created by nature during the formation of a storm.

The third-generation Santa Fe features sophisticated and refined lines, which are in harmony with bold and voluminous surfaces, completing a more aggressive and classic look than its predecessor.

The design adopts the hexagonal grille ? a key design cue of the Hyundai family look ? a two-tone voluminous bottom car body and wider front and rear bumpers, creating a futuristic and urban-style SUV image.

Dynamic side character lines give a more aerodynamic feeling, while emotional details expressed on the exterior design deliver a premium image, suggesting a new design direction for Hyundai?s next-generation SUVs.

The all-new Santa Fe, whose core product concepts are ?Refinement,? ?Smartness? and ?Practicality, ? is expected to be a hit in the global SUV market, offering the best value to customers in every aspect, with its differentiated design, cutting-edge technologies, good fuel economy and practical use of space.

Via Hyundainews.com

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Source: http://hellerhyundai.wordpress.com/2012/03/19/sneak-peak-of-the-2013-santa-fe/

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Monday, March 19, 2012

asics ? Blog Archive ? ?? ugg Health and Fitness Autism Article ...

Genetically-conditioned distinctions within susceptibility of some babies might acquaint them vulnerable to devastating illness during the process of vaccination. One recent learn with regard to excess neurons present within those with autism allows as some important considerations. If there namely absolutely an autism subset with genetic elements that predispose them apt have excess neurons,abercrombie & fitch co, and if they can be identified as at-risk for autism through diagnostic imaging by one early stage amid evolution ought these infants opt out of the usually prescribed vaccination schedule Many research endeavors that aspire for earliest at-risk autism detection grant for a mindset where those determined apt be at-risk ought opt out of the vaccination process. Will evolving understandings surrounded causality variables outcome within a medicinal need for fewer vaccination,???ugg, and how ambition this be tolerated by the ?herd??
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Source: http://asics.manablog.jp/archives/11850

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Sunday, March 18, 2012

How To BOOST Your Online Sales By 50-120% In The Next 7 Days ...

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Sales? are the life blood and driving force of your business and are what keep your business and employees(if you have any) going, whether your business is online or offline, moving you closer to your desired goals set for that year because without ?Sales? your business would siese to exist.

This is a ?Fact? and anyone reading this right now knows it.

Now, for the purpose of this article, I?m going to be strictly focusing on ?Online Sales? and how you can BOOST them by 50-120% in the next 7 days by simply implementing this one strategy.

YES? I?m not joking. This really can be done if you know how and are willing the learn the necessary ?Steps? in order to get it done.

All the TOP Internet marketers are using this strategy to build their online empires effortlessly, and you too can do the same.

Not only will this strategy build your online empire and BOOST your online sales, it is also one of the most POWERFUL traffic generating tactics on the Internet for ANY business out there.

Okay. I hope by now I have your attention.

Now, we all know that if we don?t promote our business or businesses online, whether it?s a Product, Service or Business Opportunity, and get it infront of your target market, our business would simply disappear to no existance.

Can we agree on that?

I thought so.

With that said, there are several marketing tactics that we as Internet marketers can employ online like, Articles, Pay-Per-Clicks, SEO, Blogs, eMail, Traffic Exchanges, just to name a few, to use to get our Products, Services or Business Opportunity infront of our target market in order to make a ?Sale? or enroll a NEW referral.

All these methods do take time to learn and time to implement. Some do cost money and depending on your marketing budget, might not get you the desired results you were hoping for.

The good news is the strategy I?m about to share with you will take all that away, though there is always some time and learning involved, and will build you an online sales force that will start sending your website Hundreds, if not, Thousands of qualified visitors to your website, costing you Nothing, and bringing in those much needed ?Sales?.

Now, if you?ve been online for any length of time then you?ve probably heard of what I?m about to mention, if not, then your in for a real treat.

Here it is? the most POWERFUL marketing tactic available online for generating Hundreds, if not, Thousands of targeted visitors to your website and BOOST your sales by up to 50-120% in the next 7 days is an?

? Affiliate Program!

For those of you who don?t know what a Affiliate Program is it?s simply a way for companies to extend and distribute their products and services through a Virtual Sales Force made up of any number of any kind of other web sites.

This is VERY powerful strategy used by almost all or anybody serious about their business and when implemented properly could send your sales through the roof.

Simply put, by having your own Affiliate Program in place it gives you the ability to put Joint Ventures together, find and recruit affiliates, or even better, SUPER Affiliates who will market your Product, Service or Business Opportunity at their expense, costing you nothing, in exchange for a cut of the profits, which is usually a percentage or set price.

Point being, the more affiliates you find and recruit, the BIGGER your Sales Force will be, sending you Hundreds, if not, Thousands of qualified targeted visitors to your website which is what you need in order to make ?Sales?.

It?s not such a bad trade off, wouldn?t you agree?

Just imagine for a moment if you had just 100 affiliates working Day and Night promoting your Product, Service or Business Opportunity, sending your website traffic that you had to do nothing to get and are bringing you in those much needed Sales and/or Referrals to reach your set goals.

Can you see it?

For some of you this might be a BIG step, while for others, this just might be what you?ve be looking for to take your online business to the next level.

It?s now up to you to make a decision on whether or not this is something you want to pursue and guarantee once you get all the facts, you?ll agree.

I truly hope you benefited from this article and hope it opened your eyes to what you might want to consider for your business in the coming months ahead.

Download HubSpot?s free eBook, ?The Ultimate How-To Marketing Guide?, and amplify your marketing!

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Source: http://virtualblackswanmarketing.mobi/?p=9784

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When web marketing was fairly new, you had the extra edge when it came to earning profits if you had a better understanding of how things worked on the web. The internet marketers that were the first to utilize autoresponders and leverage Google Adwords put themselves in a position to profit because there was almost no competition at the time. The world of web marketing has changed considerably since that time and it is more important than ever to build good relationships with new and current customers. The following paragraphs will go over various aspects of relationship marketing and the methods you can employ to develop your business. For online backup you need one of the best online backup services.

Even though e-mail marketing isn?t the only way to touch base fast with consumers these days, it is still very important in establishing a business online. List building is different as the main focus is no longer on increasing your number of subscribers. In fact, individuals who join your list will probably be on the list of other internet marketers as well, and so you want to be certain that they elect to open and read your emails. Currently, it can be difficult to get your emails opened, so you must take steps to be the go to person for your subscribers so they?ll always open your emails. In life, when you givea whole lot you often get a whole lot in return. You?ll see that your clients are more willing to purchase things that you recommend if you have previously provided them valuable information without cost. You can take online server backup now its easy and secure now.

So if we affirm that email marketing remains important, we must also recognize that social media has introduced a completely new era for relationship marketing. Facebook, Twitter, and LinkedIn are today important aspects of the lives of numerous people and the subjects they discuss can make or break an online business. As online marketers it can be very beneficial to have a presence on these websites if you have the intention to provide a positive experience for those you interact with. If you interact with people in a fashion that encourages their trust, they?re more likely to subscribe to your email list or click through to your website. This is the aim since then you can turn visitors into purchasers through your email correspondence or onsite marketing.

If you increase what you know about these social websites, your way of relationship building will allow you to create a dedicated list of followers. Numerous internet marketers have done this with success and you can follow in their footsteps by observing the manner in which they make use of these websites. Akin to any other internet marketing approach, if you observe individuals who have been successful, you can prevent yourself from making some of the same irreparable blunders.

Right now relationship marketing is a priority on the Internet, and if you can offer value while being a person of ethics and someone folks can trust, you can expect to succeed.

Source: http://icecreamstyle.com/relationship-marketing-how-you-can-be-an-online-success/1633/

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Saturday, March 17, 2012

Marketing Real Estate With Video - How to Embed Video on ...

Part of a series of video tutorials on how to market real estate through video.
Presented by Unique Exposure Photography.
http://www.FortWorthRealEstatePhotography.com

This tutorial on marketing real estate with video discusses how to increase video exposure by embedding YouTube videos into websites and blogs.

YouTube makes it easy to share your real estate video and post it directly on your website or blog. Sites like ActiveRain make it easy to spread your video through blogging. This tutorial shows you how to use the Embed feature to place your real estate video on other websites to increase exposure.

** All advice given is simply a suggestion/opinion to help those starting out with marketing their real estate videos. I make no guarantees as to the success of your marketing efforts, but I wish you all the best! **

Music: Chipper Doodle v2, Creative Commons License, incompetech.com

Source: http://www.youtube.com/watch?v=Zl2QCHjUX4c

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A study published this week in the Journal of Neuroscience shows ...




A study published this week in the Journal of Neuroscience shows that the compound epothilone D (EpoD) is effective in preventing further neurological damage and improving cognitive performance in a mouse model of Alzheimer's disease (AD). The results establish how the drug might be used in early-stage AD patients. Investigators from the Perelman School of Medicine at the University of Pennsylvania, led by first author Bin Zhang, MD, PhD, senior research investigator, and senior author Kurt R...

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Source: http://www.kiefit.com/Health_Fitness/potential-alzheimers-disease-drug-slows-damage-and-symptoms-in-animal-model/

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Friday, March 16, 2012

George Clooney released after arrest

Win Mcnamee / Getty Images

Plastic handcuffs were used on actor George Clooney, who was arrested Friday for a protest at the Sudanese embassy in Washington.

By Gael Fashingbauer Cooper

UPDATE, 2:30 p.m. ET: George Clooney, his father, Nick, and other activists who were arrested at the Sudanese embassy in Washington on Friday were released from jail the same afternoon.

Clooney spoke to reporters about the arrest, saying, "You never know if you are accomplishing anything. ... We hope it helps."

He went on to say, "There really is a ticking clock on (the situation)," and expressed hope that food and aid would come to the starving people of Sudan before their devastating rainy season begins.

Asked about the conditions in jail, the actor joked, "It was rough, you can imagine." He said the men were all put in the same cell and paid a fine before being released.

The actor said the incident was his first-ever arrest. "Let's hope it's my last," he added.

One reporter asked how Clooney's girlfriend, actress and former pro wrestler Stacy Keibler, would react to the arrest. "She's probably thrilled," Clooney deadpanned.

ORIGINAL STORY: No, it wasn't for a movie. Actor George Clooney, long a political activist, was arrested and handcuffed outside the Sudanese embassy in Washington for protesting the country's blockage of food and aid?to its own starving people.

Clooney's father, journalist Nick Clooney, 78, was?with him and was also arrested, as were Martin Luther King III, NAACP President Ben Jealous, comedian and activist Dick Gregory, Rep. Jim McGovern (D-Mass.), Rep. Jim Moran (D-Va.), Rep. John Olver (D-Mass.), Rep. Al Green (D-Texas) and?former Rep. Tom Andrews (D-Mass.). The group was restrained with plastic handcuffs and taken away?by police.?

Speaking before the large crowd that gathered to?watch the protest, Clooney said, "We need immediate humanitarian aid into Sudan before it becomes the worst humanitarian crisis in the world."

He went on to say that the group wanted "the (Sudanese) government in Khartoum to stop randomly killing its own innocent men, women and children. Stop raping them, and stop starving them."

Half a million people in Sudan's Nuba Mountains and Blue Nile regions risk starvation due to the blockage of supplies, and the coming rainy season will only make it worse, the actor told the crowd.

"It?s about to start raining, and once it starts raining there, thousands of people are going to die," Clooney said.

Before his arrest, Clooney told NBC's Andrea Mitchell, "It's actually a humiliating thing to be arrested no matter what you do, but I'm proud to be standing here with my father."

He went on to say, "When people ask you, 'Where were you and where did you stand?' I want to say I was standing on the right side of history."

King, the eldest son of civil-rights leader Dr. Martin Luther King Jr., said the protest and arrests reminded him of his father's experiences in the 1960s. He said, "The issue is to raise the consciousness of the world. When the world speaks, then (Sudanese) President (Omar al-) Bashir has to listen."

NAACP president Jealous said the group's message was simple. "We need to stop using rape and food as weapons in Sudan," he told Mitchell. "We are here to show President Bashir that this is what the end looks like."

Because the embassy is private property, Clooney and colleagues knew that refusing to move would end in arrest. They were warned three times before police moved in to make the arrests. Mitchell noted that she, too, was asked by police if she intended to be arrested, and told to move off the embassy steps if not.

The group held a sign that read "Sudan: Stop Weapons of Mass Starvation."

On Thursday,?the actor testified?before the Senate Foreign Relations Committee about what he saw in Sudan,?then met?with Secretary Hillary Clinton and President Obama in the Oval Office. The Washington Post later reported?that Clooney said Obama promised to push China's president to aid in forcing Sudan to open its southern region to relief efforts.

He later told reporters that "people turn on the news and see an awful lot of bad stories," but added that the United States "is still the most generous country in the world and truly the most compassionate."

On Wednesday, Clooney appeared on TODAY with Ann Curry and discussed how he came under rocket fire in the Sudan on a recent trip there.

He also attended?Wednesday night's White House State Dinner for British Prime Minister David Cameron.

Can Clooney's star power make a difference? Tell us on Facebook.

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Source: http://todayentertainment.today.msnbc.msn.com/_news/2012/03/16/10718149-george-clooney-released-after-arrest-at-sudanese-embassy

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Workers to raise Bangladesh ferry after 110 die

DHAKA, Bangladesh (AP) ? Recovery workers were trying to raise the wreckage of a ferry that capsized on a river in Bangladesh while carrying about 200 people, hoping Wednesday's efforts would reveal the fate of dozens of passengers still missing. The death toll rose to 110.

The ferry collided with a cargo boat and capsized in the darkness of Tuesday morning, sending hundreds of people into the Meghna River, just south of the capital, Dhaka. Local police chief Mohammad Shahabuddin Khan said about 35 survivors were plucked from the water, while local media reported that another 40 managed to swim to shore.

The death toll climbed to 110 by late Wednesday afternoon after villagers and rescuers found more bodies inside the ferry and floating in nearby waters, said rescue official Mahfuzul Haque. Divers had recovered 31 bodies inside the sunken vessel the day before, and efforts to move the ferry had shaken more loose.

The dead included a young woman found cradling her baby's lifeless body, police chief Khan said.

Ferry accidents are common in Bangladesh, a low-lying delta nation of 160 million people. They are often blamed on overcrowding, faulty vessels and lax rules.

Hundreds of anxious people, many of them weeping, gathered near the scene of the accident to look for their loved ones. Some of them were angry, saying they blamed local authorities for the slow pace of the rescue operation.

Parul, who goes by one name, said she had been waiting at the shore since Tuesday night for news of her newly married brother, who was returning on the ferry with 16 others from his wedding party.

She said only four of the 17 had apparently survived. Two bodies had been recovered, but the bridegroom and others were still missing.

"Bring my brother back, give them all back," Parul wailed as she beat her chest. "I want to see their faces, please take me to them."

The ferry sank in about 70 feet (21 meters) of water. On Wednesday, it was pulled up to the water level, and rescue ships were slowly attempting to tow it to the bank.

Khan could not specify how many people were missing, but said many were feared dead. It is difficult to get a reliable estimate for the number of passengers as ferry operators rarely keep a list and most passengers buy tickets once on board.

Some of the bodies inside the sunken ferry were buried under cargo, said Mohammad Alauddin, a diver who was among the searchers.

The recovered bodies have been kept in rows on the sandy bank, where volunteers and officials were trying to identify them.

The MV Shariatpur-1 was traveling to Dhaka from neighboring Shariatpur district to the southwest. The accident site is in Munshiganj district, about 20 miles (32 kilometers) south of Dhaka.

___

Associated Press writer Julhas Alam in Dhaka contributed to this report.

Source: http://news.yahoo.com/workers-raise-bangladesh-ferry-110-die-112415842.html

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Thursday, March 15, 2012

Video-game review: 'MLB 12 The Show,' 'Nicktoons MLB 3D' | Free ...

Posted in March 14, 2012 ? 5:06 pmh.admin

Video-game review: 'MLB 12 The Show,' 'Nicktoons MLB 3D'
"MLB12's" flashiest new feature ? Diamond Dynasty, available only in the PS3 version ? attempts to replicate the success of EA Sports' Ultimate Team modes, in which you assemble teams of players from virtual packs of cards you buy with in-game (or, ?
Read more on Bellingham Herald

An Iguana Strikes in New 'The Amazing Spider-Man' Game Trailer [Video]
Initial teasers for The Amazing Spider-Man videogame were heavy on crazy robots. Wonderful as that may be, a new promo vid at IGN indicates the movie tie-in will have plenty of more organic foes to face as well. Dubbed "The Amazing Spider-Man's Iguana ?
Read more on ComicsAlliance

Video Game Review: Plants vs. Zombies
By Ebenezer Samuel / NEW YORK DAILY NEWS There was a time, just a few short years ago, when Apple iPad games were measured against portable console gaming experiences. We wondered if they could hang, if the likes of Cut the Rope would ever captivate us ?
Read more on New York Daily News

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Source: http://www.free-play.org/video-game-review-mlb-12-the-show-nicktoons-mlb-3d/

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Wednesday, March 14, 2012

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Tuesday, March 13, 2012

Rules For New Insurance Marketplaces Give Insurers Clout - Kaiser ...

Insurers?and?other industry?representatives will get to?fill as many as half the seats on the governing boards for state health insurance exchanges, under?final rules for the marketplaces issued today by the Department of Health and Human Services.? At least one seat?must be reserved for a consumer representative.

The long-awaited rules are likely to disappoint consumer advocates who would have preferred the governing boards ?be dominated by consumers,? said Timothy Jost, who speaks as a consumer advocate before the National Association of Insurance Commissioners and is a professor at the Washington and Lee University School of Law.? But Jost said he is pleased the final rules require at least one consumer representative. ?It at least gives a toe-hold,? he said.

But they may also frustrate insurers who had sought to prevent the?governing boards?from imposing requirements on plans beyond what is included in the 2010?health care law.?HHS left that possibility in place, however, writing, ?We continue to believe that states are best equipped to adapt the minimum exchange functions to their local markets and the unique needs of their residents.?

The exchanges are seen as a key element in the health law, offering one-stop shops for individuals and small businesses looking to purchase health insurance. They will also help determine applicants? eligibility for programs such as Medicaid, and for federal subsidies to help them purchase insurance. An expected 21 million people will purchase coverage through the exchanges by 2017, according to Congressional Budget Office projections.

The Obama administration touted the 646-page rules as granting states great flexibility in how they design their exchanges, the types of organizations ? nonprofit or public agency ? that will oversee them and whether to partner with the federal government to operate parts of it. The rules were published as some states are working to set up exchanges and their governing boards ? while others have balked at moving forward until after the Supreme Court rules on the constitutionality of the federal health law, which is expected in June.

Additionally, Monday?s announcement included some ?interim? rules, meaning they could be tweaked following a 45-day public-comment period. Those interim rules cover issues such as how quickly states must determine if an applicant is eligible for Medicaid or the Children?s Health Insurance Program, and the role insurance brokers will play in helping low- and middle-income people apply for federal subsidies to buy coverage.

Administration officials said the new rules differ from preliminary regulations in several ways. Earlier guidance had proposed that?each exchange?be responsible for determining which applicants are eligible for insurance subsidies. ?The final rule gives states the option to allow HHS to conduct eligibility review. To determine who is eligible for Medicaid or the Children?s Health Insurance Plan, states can choose their own Medicaid agencies.??It also?says states cannot allow insurance agents to determine an applicant?s eligibility for subsidies or Medicaid, which remain government functions. But agents, including those who work for web-based private exchanges, can assist those applicants in sorting through their health plan options.

The rules appear to strike a balance between responding to thousands of comments about earlier proposals and providing more details ?so states can move forward,? says Patti Boozang, managing director at Manatt Health Solutions, a law and consulting firm based in New York.

The rules?do not explain how the federal government would set up exchanges in states that are unable or unwilling to develop their own marketplaces, with those details promised in future rules. In January, the Obama administration?released a report?saying about 28 states are ?on their way? toward establishing exchanges.? ?There?s no new information on how that would work, what the partnership model would look like or what states would have to pay ? and that?s all information many states have anxiously awaited,? says Boozang.

Karen Ignagni, President and CEO of America?s Health Insurance Plans (AHIP), a trade group, said her organization would be reviewing the rule and offering feedback.

?Exchanges will work best if they are true marketplaces that maximize choice and competition so that individuals, families, and small businesses can purchase plans that are right for them," she said in a prepared statement. "Consumers will be best served if a state exchange adopts an efficient, cost-effective approach that leverages existing health plan resources, utilizes federal resources or guidance where sensible, and relies on the exchange itself to administer key functions."

The law says the exchanges will start taking applications in Oct. 1,? 2013 ? and policies purchased through them would take effect Jan. 1, 2014.? States that are allowed to operate their own exchanges must have approval or conditional approval from HHS by Jan 1, 2013, according to the rules.

In a nod to the fact that some states won?t be able to meet that deadline, the final rules say HHS can grant conditional approval to states that show they are likely to be fully operational by October 2013. Details on what it will take to prove that are expected in future rules.

All original KHN material ? articles, graphics and videos ? can be used for free, if you credit us and link to us. Learn more

Source: http://www.kaiserhealthnews.org/Stories/2012/March/12/insurance-exchange-rules-hhs-states.aspx

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Monday, March 12, 2012

UCLA scientists find insulin, nutrition prevent blood stem cell differentiation in fruit flies

UCLA scientists find insulin, nutrition prevent blood stem cell differentiation in fruit flies [ Back to EurekAlert! ] Public release date: 11-Mar-2012
[ | E-mail | Share Share ]

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles Health Sciences

UCLA stem cell researchers have shown that insulin and nutrition keep blood stem cells from differentiating into mature blood cells in Drosophila, the common fruit fly, a finding that has implications for studying inflammatory response and blood development in response to dietary changes in humans.

Keeping blood stem cells, or progenitor cells, from differentiating into blood cells is important as they are needed to create the blood supply for the adult fruit fly.

The study found that the blood stem cells are receiving systemic signals from insulin and nutritional factors, in this case essential amino acids, that helped them to maintain their "stemness," said study senior author Utpal Banerjee, professor and chairman of the molecular, cell and developmental biology department in Life Sciences and a researcher with the Eli and Edythe Broad Center of Regenerative Medicine at UCLA.

"We expect that this study will promote further investigation of possible direct signal sensing mechanisms by mammalian blood stem cells," Banerjee said. "Such studies will probably yield insights into chronic inflammation and the myeloid cell accumulation seen in patients with type II diabetes and other metabolic disorders."

The study appears March 11, 2012 in the peer-reviewed journal Nature Cell Biology.

In the flies, the insulin signaling came from the brain, which is an organ similar to the human pancreas, which produces insulin. That insulin was taken up by the blood stem cells, as were amino acids found in the fly flood, said Ji Won Shim, a postdoctoral fellow in Banerjee's lab and first author of the study.

Shim studied the flies while in the larval stage of development. To see what would happen to the blood stem cells, Shim placed the larvae into a jar with no food - they usually eat yeast or cornmeal and left them for 24 hours. Afterward, she checked for the presence of blood stem cells using specific chemical markers that made them visible under a confocal microscope.

"Once the flies were starved and not receiving the insulin and nutritional signaling, all the blood stem cells were gone," Shim said. "All that were left were differentiated mature blood cells. This type of mechanism has not been identified in mammals or humans, and it will be intriguing to see if there are similar mechanisms at work there."

In the fruit fly, the only mature blood cells present are myeloid cells, Shim said. Diabetic patients have many activated myeloid cells that could be causing disease symptoms. It may be that abnormal activation of myeloid cells and abnormal metabolism play a major role in diabetes.

"Metabolic regulation and immune response are highly integrated in order to function properly dependent on each other. Type II diabetes and obesity, both metabolic diseases, are closely associated with chronic inflammation, which is induced by abnormal activation of blood cells," Shim said. "However, no systemic study on a connection between blood stem cells and metabolic alterations had been done. Our study highlights the potential linkage between myeloid-lineage blood stem cells and metabolic disruptions."

Going forward, Banerjee and his team are seeking other system signaling molecules that may be controlling blood stem cells in the fruit fly.

"It is known that metabolic dysfunction in mammals causes abnormal inflammatory responses in the blood system. However, how metabolic stresses impinge on blood cell development is still unclear," the study states. "Here, we found that starvation of Drosophila larvae leads to blood cell phenotypes. The most striking effect is acceleration of blood cell differentiation both in time and number of cells affected."

###

The two-year study was supported by the National Institutes of Health and a training grant from the Broad Stem Cell Research Center at UCLA.

The stem cell center was launched in 2005 with a UCLA commitment of $20 million over five years. A $20 million gift from the Eli and Edythe Broad Foundation in 2007 resulted in the renaming of the center. With more than 200 members, the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research is committed to a multi-disciplinary, integrated collaboration of scientific, academic and medical disciplines for the purpose of understanding human adult and embryonic stem cells. The center supports innovation, excellence and the highest ethical standards focused on stem cell research with the intent of facilitating basic scientific inquiry directed towards future clinical applications to treat disease. The center is a collaboration of the David Geffen School of Medicine, UCLA's Jonsson Cancer Center, the Henry Samueli School of Engineering and Applied Science and the UCLA College of Letters and Science. To learn more about the center, visit our web site at http://www.stemcell.ucla.edu.


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


UCLA scientists find insulin, nutrition prevent blood stem cell differentiation in fruit flies [ Back to EurekAlert! ] Public release date: 11-Mar-2012
[ | E-mail | Share Share ]

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles Health Sciences

UCLA stem cell researchers have shown that insulin and nutrition keep blood stem cells from differentiating into mature blood cells in Drosophila, the common fruit fly, a finding that has implications for studying inflammatory response and blood development in response to dietary changes in humans.

Keeping blood stem cells, or progenitor cells, from differentiating into blood cells is important as they are needed to create the blood supply for the adult fruit fly.

The study found that the blood stem cells are receiving systemic signals from insulin and nutritional factors, in this case essential amino acids, that helped them to maintain their "stemness," said study senior author Utpal Banerjee, professor and chairman of the molecular, cell and developmental biology department in Life Sciences and a researcher with the Eli and Edythe Broad Center of Regenerative Medicine at UCLA.

"We expect that this study will promote further investigation of possible direct signal sensing mechanisms by mammalian blood stem cells," Banerjee said. "Such studies will probably yield insights into chronic inflammation and the myeloid cell accumulation seen in patients with type II diabetes and other metabolic disorders."

The study appears March 11, 2012 in the peer-reviewed journal Nature Cell Biology.

In the flies, the insulin signaling came from the brain, which is an organ similar to the human pancreas, which produces insulin. That insulin was taken up by the blood stem cells, as were amino acids found in the fly flood, said Ji Won Shim, a postdoctoral fellow in Banerjee's lab and first author of the study.

Shim studied the flies while in the larval stage of development. To see what would happen to the blood stem cells, Shim placed the larvae into a jar with no food - they usually eat yeast or cornmeal and left them for 24 hours. Afterward, she checked for the presence of blood stem cells using specific chemical markers that made them visible under a confocal microscope.

"Once the flies were starved and not receiving the insulin and nutritional signaling, all the blood stem cells were gone," Shim said. "All that were left were differentiated mature blood cells. This type of mechanism has not been identified in mammals or humans, and it will be intriguing to see if there are similar mechanisms at work there."

In the fruit fly, the only mature blood cells present are myeloid cells, Shim said. Diabetic patients have many activated myeloid cells that could be causing disease symptoms. It may be that abnormal activation of myeloid cells and abnormal metabolism play a major role in diabetes.

"Metabolic regulation and immune response are highly integrated in order to function properly dependent on each other. Type II diabetes and obesity, both metabolic diseases, are closely associated with chronic inflammation, which is induced by abnormal activation of blood cells," Shim said. "However, no systemic study on a connection between blood stem cells and metabolic alterations had been done. Our study highlights the potential linkage between myeloid-lineage blood stem cells and metabolic disruptions."

Going forward, Banerjee and his team are seeking other system signaling molecules that may be controlling blood stem cells in the fruit fly.

"It is known that metabolic dysfunction in mammals causes abnormal inflammatory responses in the blood system. However, how metabolic stresses impinge on blood cell development is still unclear," the study states. "Here, we found that starvation of Drosophila larvae leads to blood cell phenotypes. The most striking effect is acceleration of blood cell differentiation both in time and number of cells affected."

###

The two-year study was supported by the National Institutes of Health and a training grant from the Broad Stem Cell Research Center at UCLA.

The stem cell center was launched in 2005 with a UCLA commitment of $20 million over five years. A $20 million gift from the Eli and Edythe Broad Foundation in 2007 resulted in the renaming of the center. With more than 200 members, the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research is committed to a multi-disciplinary, integrated collaboration of scientific, academic and medical disciplines for the purpose of understanding human adult and embryonic stem cells. The center supports innovation, excellence and the highest ethical standards focused on stem cell research with the intent of facilitating basic scientific inquiry directed towards future clinical applications to treat disease. The center is a collaboration of the David Geffen School of Medicine, UCLA's Jonsson Cancer Center, the Henry Samueli School of Engineering and Applied Science and the UCLA College of Letters and Science. To learn more about the center, visit our web site at http://www.stemcell.ucla.edu.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-03/uoc--usf030912.php

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